Detection of R576 interleukin-4 receptor αn allele gene, serum interleukin-4, and eosinophilic cationic protein in atopic dermatitis patients
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چکیده
منابع مشابه
Serum Interleukin-17 Evaluation in Patients With Eosinophilic Gastrointestinal Disease
Background: Eosinophilic gastrointestinal disorders or diseases (EGIDs) may result from an abnormal immune-mediated response to food antigens. Activated eosinophils release various mediators with inflammatory properties which may result in tissue and subsequently organ damage. The cytokine milieu of these patients has revealed increased levels of pro-inflammatory cytokines, inc...
متن کاملLinkage and association of an interleukin 4 gene polymorphism with atopic dermatitis in Japanese families.
We examined linkage between markers at and near the IL4 gene and atopic dermatitis (AD) in 88 Japanese nuclear families. Affected sib pair analysis suggested linkage between the IL4 gene and AD (SPLINK lod=2.28). Transmission disequilibrium testing showed a significantly preferential transmission to AD offspring of the T allele of the -590C/T polymorphism of the IL4 gene (p=0.001). A case-contr...
متن کاملAssociation between single nucleotide polymorphisms of the interleukin-4 gene and atopic dermatitis.
Atopic dermatitis (AD) is an inflammatory skin disease in which both genetic and environmental factors seem to be involved. Several studies investigated the association of certain genetic factors with AD in different ethnic groups, but conflicting data were obtained. This study was performed to check the possible association between single nucleotide polymorphisms (SNPs) of interleukin 4 (IL-4)...
متن کاملIn vitro interleukin 4 and interferon-gamma production by mononuclear cells from atopic dermatitis patients
In order to elucidate further the possible role of specific cytokines in the pathogenesis of atopic dermatitis (AD) the in vitro production of interleukin 4 (IL-4) and interferon-gamma (IFN-gamma) in patients with severe atopic dermatitis (n = 4) was compared with that in a group of non-atopic healthy controls. Overall IL-4 production by PHA- and PWM-driven PBMNCs was increased in controls duri...
متن کاملLow neonatal Toll-like receptor 4-mediated interleukin-10 production is associated with subsequent atopic dermatitis.
BACKGROUND Atopic dermatitis (AD) and respiratory syncytial virus lower respiratory tract infection (RSV LRTI) are common diseases during early life. Impaired Th1-cell polarizing Toll-like receptor (TLR) responses play an important role in the pathogenesis of both diseases. Neonatal TLR-mediated production of Th1-type cytokines is decreased at birth, but rapidly increases during the first month...
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ژورنال
عنوان ژورنال: Indian Journal of Dermatology
سال: 2009
ISSN: 0019-5154
DOI: 10.4103/0019-5154.48983